New Manuscript Published

Research brief: The plant rhizosphere—renowned for its nutrient-rich milieu—continues to stand as a vibrant hotspot of extraordinary microbial diversity, harboring genetic blueprints for an array of chemically distinctive compounds. In a significant scientific breakthrough, an exploration led by Scientists from the Microbiology Division, JNTBGRI, has unveiled a therapeutically promising microbe, Streptomyces melanogenes WPF1, from Pinus patula rhizosphere. Employing an integrated strategy that seamlessly combined whole-genome mining with advanced metabolomic profiling, the team successfully identified the long-overlooked clinical compound Kinamycin D. This landmark study reaffirms the untapped potential of this neglected therapeutic, highlighting its remarkable efficacy as an antimicrobial, antibiofilm, and anticancer agent, and opening new avenues for translational biomedical research.

Manuscript title: Whole genome surveying and metabolomic profiling aided navigation of therapeutic plethora of Streptomyces melanogenes WPF1 isolated from Pinus patula rhizosphere

Journal: Bioresources and Bioprocessing, Springer Nature
https://doi.org/10.1186/s40643-025-00973-7
Impact factor: 5.1
Correspondence: Dr Vipin Mohan Dan, Microbiology division,KSCSTE-JNTBGRI